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Adaptive Optics, Imager, and Analityc Software for Medical Retinal Imaging

Supervisor: Dr. Larichev A.V.


Fig. 1

Project Title:

Adaptive Optics, Imager and Analytic Software for Medical Retinal Imaging

Project Number:

SfP 97-4292

Project Co-Directors:

Partner Country Project Director: Dr. Andrey Larichev, Ph.D., Institute on Laser and Information Technologies (ILIT RAS) Svyatoozerskaya Str. 1, Shatura, 140700 Moscow Region, Russia

NATO Country Project Director: Dr. Leonard John Otten III, Ph.D., Kestrel Corporation, Vice President, 6624 Gulton Court, NE, Albuquerque, New Mexico, 87109, USA


In the framework of the Project a novel multispectral retinal imager with adaptive compensation of eye aberrations was created. The overall objective of this Program is to demonstrate that a combination of low-bandwidth adaptive optics and an optimized deconvolution technique can be used to increase retinal multispectral imaging resolution and that the resulting instrument will improve the level of ophthalmological healthcare.


To meet this objective we propose to complete the following tasks:

To develop the theory of retinal image formation under the anisoplanatic conditions including determining the optimal phase correction/measurements algorithms.

To design and manufacture a specialized Shack-Hartman sensor to fit a multispectral fundus camera optical system.

To design and manufacture an appropriate reference source for dynamically maintaining retinal focus. This "focus on demand" allows the best viewing of the area of interest on the retina under anisoplanatic conditions.

To modify an existing flexible mirror design to achieve the best performance in the correction of low-order human eye aberrations and adapt it to the fundus imager optical design.

To adapt the deconvolution algorithm for optimal functioning when coupled to the adaptive optics low-order corrector. To optimize the related software for PC computers.

To perform laboratory tests of the complete breadboard system against known degradations using a multispectral fundus imaging system. To collect quantitative optical performance data using the as-built hardware.

To conduct limited clinical demonstrations in Russia and the United States.


All these tasks have been completed. Two units of the retinal imager with adaptive compensation of eye aberrations have been built. The developed fundus imager has been patented in United States (#US 6331059 B1, December 18, 2001)


Technical details about the Adaptive MultiSpectral Fundus Imager can be found [ here ]